Losartan vs. amlodipine treatment in elderly oncologic hypertensive patients: a randomized clinical trial.

Abstract

Elderly neoplastic patients frequently may show hypertension and hyperuricemia, before and after chemotherapeutic treatments. The purpose of this study was to evaluate the efficacy of losartan which is an antihypertensive drug with uricosuric properties vs. amlodipine in hypertensive neoplastic elderly patients. This was an open-labeled, randomized, comparative trial. The study was performed as a 30-day study. Seventy patients with cancer were randomly assigned to receive losartan or amlodipine. Blood pressure (BP), blood urea nitrogen (BUN) levels, creatinine, serum and urinary uric acid, creatinine and uric acid clearance were determined before and after chemotherapy. One day after chemotherapy in losartan group vs. amlodipine group we observed a significant difference in urinary uric acid (p<0.001) of 18 mg/24 h vs. 40 mg/24 h. Thirty days after chemotherapy we observed a significant difference in azotemia of 0.0 mg/dl vs. 3.8 mg/dl (p<0.001), serum uric acid of 0.05 mg/dl vs. 0.49 mg/dl (p<0.001), urinary uric acid (p<0.001) of 23 mg/24 h vs. 0.0 mg/24 h, GFR of 2 ml/min/1.73 m(2) vs. -8 ml/min/1.73 m(2) (p<0.05) and systolic BP (SBP) of 3.6 mmHg vs. 0.8 mmHg (p<0.05). The findings of the present study support the effective role of losartan compared to amlodipine in treating hypertension and hyperuricemia in elderly patients under chemotherapeutic treatment.

• Authors: Massimo Motta, Cristina Russo, Marco Vacante, Rocco Luca Emanuele Liardo, Francesca Reitano, Lisa Cammalleri, Mario Costanzo, Giuseppe Benfatto, Paola Frazzetto, Enrico Mondati, Michele Malaguarnera, Giovanni Pennisi
• Journal: Archives of gerontology and geriatrics (Arch Gerontol Geriatr) 2011 Jul-Aug Vol. 53 Issue 1 Pg. 60-3 ISSN: 1872-6976 [Electronic] Netherlands
• PMID: 20569998 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antihypertensive Agents
• Antineoplastic Agents
• Amlodipine
• Uric Acid
• Creatinine
• Losartan

Topics

• Aged
• Amlodipine (therapeutic use)
• Antihypertensive Agents (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Blood Urea Nitrogen
• Creatinine (blood)
• Female
• Geriatric Assessment
• Glomerular Filtration Rate (drug effects)
• Humans
• Hypertension (complications, drug therapy)
• Hyperuricemia (chemically induced, drug therapy)
• Losartan (therapeutic use)
• Male
• Neoplasms (complications, drug therapy)
• Treatment Outcome
• Uric Acid (blood, urine)