Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.

Abstract

A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. However, few studies have examined the association of circulating 25-hydroxyvitamin D (25(OH)D), an integrated measure of vitamin D status, with ovarian cancer risk. A nested case-control study was conducted among 7 prospective studies to evaluate the circulating 25(OH)D concentration in relation to epithelial ovarian cancer risk. Logistic regression models were used to estimate odds ratios and 95% confidence intervals among 516 cases and 770 matched controls. Compared with 25(OH)D concentrations of 50-<75 nmol/L, no statistically significant associations were observed for <37.5 (odds ratio (OR) = 1.21, 95% confidence interval (CI): 0.87, 1.70), 37.5-<50 (OR = 1.03, 95% CI: 0.75, 1.41), or > or =75 (OR = 1.11, 95% CI: 0.79, 1.55) nmol/L. Analyses stratified by tumor subtype, age, body mass index, and other variables were generally null but suggested an inverse association between 25(OH)D and ovarian cancer risk among women with a body mass index of > or =25 kg/m(2) (P(interaction) < 0.01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women.

• Authors: Wei Zheng, Kim N Danforth, Shelley S Tworoger, Marc T Goodman, Alan A Arslan, Alpa V Patel, Marjorie L McCullough, Stephanie J Weinstein, Laurence N Kolonel, Mark P Purdue, Xiao-Ou Shu, Kirk Snyder, Emily Steplowski, Kala Visvanathan, Kai Yu, Anne Zeleniuch-Jacquotte, Yu-Tang Gao, Susan E Hankinson, Chinonye Harvey, Richard B Hayes, Brian E Henderson, Ronald L Horst, Kathy J Helzlsouer
• Journal: American journal of epidemiology (Am J Epidemiol) Vol. 172 Issue 1 Pg. 70-80 (Jul 01 2010) ISSN: 1476-6256 [Electronic] United States
• PMID: 20562186 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Vitamin D

Topics

• Adult
• Case-Control Studies
• China (epidemiology)
• Cohort Studies
• Female
• Finland (epidemiology)
• Humans
• Logistic Models
• Ovarian Neoplasms (epidemiology, prevention & control)
• Overweight (epidemiology)
• Prospective Studies
• Risk Factors
• United States (epidemiology)
• Vitamin D (blood, therapeutic use)
• Vitamin D Deficiency (complications, epidemiology, prevention & control)