Tamsulosin as an expulsive therapy for steinstrasse after extracorporeal shock wave lithotripsy: a randomized controlled study.

Abstract

OBJECTIVE:

Steinstrasse is a well-known complication following extracorporeal shockwave lithotripsy (ESWL). The objective of this study was to evaluate the efficacy of tamsulosin as a management of steinstrasse.

MATERIAL AND METHODS:

88 patients with unilateral steinstrasse were treated between January 2005 and December 2008. The patients were randomly allocated into two equal groups. There were no significant differences between groups for age, gender, stone location, stone length or stone fragment size (p > 0.05). Patients in group 1 (study group) received a single daily morning dose of tamsulosin (0.4 mg) for a maximum of 4 weeks, in addition to pain-relieving therapy. Patients in group 2 (control group) received only the pain-relieving therapy. All patients were checked weekly with a plain X-ray of the urinary tract, urinary ultrasonography, urine analysis and serum creatinine. Pain episodes, day of spontaneous stone expulsion, total analgesic dosage and drug side-effects were recorded.

RESULTS:

Stone expulsion occurred in 32 of the 44 patients (72.7%) receiving tamsulosin and in 25 of the 44 patients (56.8%) in the control group. Patients receiving tamsulosin had a significantly higher stone expulsion rate (p = 0.017). There were no significant differences between groups for mean stone expulsion time or number of analgesics used. Twelve patients (27.3%) in the group receiving tamsulosin and 19 patients (43.3%) in the control group needed hospitalization; the group difference was statistically significant (p = 0.017).

CONCLUSIONS:

When compared with no treatment, tamsulosin can significantly facilitate expulsion of retained ureteral stone fragments following ESWL.

• Authors: Essam Moursy, Wael M Gamal, Abdelmenem Abuzeid
• Journal: Scandinavian journal of urology and nephrology (Scand J Urol Nephrol) Vol. 44 Issue 5 Pg. 315-9 (Nov 2010) ISSN: 1651-2065 [Electronic] England
• PMID: 20560802 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic alpha-1 Receptor Antagonists
• Sulfonamides
• Tamsulosin

Topics

• Adrenergic alpha-1 Receptor Antagonists (therapeutic use)
• Adult
• Humans
• Lithotripsy (adverse effects)
• Male
• Prospective Studies
• Radiography
• Sulfonamides (therapeutic use)
• Tamsulosin
• Treatment Outcome
• Ureteral Calculi (diagnostic imaging, drug therapy, etiology)