Ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Abstract

The causative factors and ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis are reported here. Six out of seven patients developed the syndrome secondary to ingestion of sulphadoxine/pyrimethamine while one developed it as a complication of HAART (highly active antiretroviral therapy). The ocular complications were ankyloblepharon, symblepharon, chronic conjunctivitis, corneal vascularization and conjunctivalization, and blindness. One patient died. A shift to the WHO-recommened artemisin-based combination therapy for the treatment of malaria is advised. Early referral to the ophthalmologist will help to reduce the complications.

• Authors: Catherine U Ukponmwan, Itiyafe Njinaka, Efe T Ehimiyen
• Journal: Tropical doctor (Trop Doct) Vol. 40 Issue 3 Pg. 167-8 (Jul 2010) ISSN: 1758-1133 [Electronic] England
• PMID: 20555046 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Ophthalmic Solutions
• Trimethoprim, Sulfamethoxazole Drug Combination

Topics

• Adolescent
• Adult
• Anti-Bacterial Agents (administration & dosage)
• Antiretroviral Therapy, Highly Active (adverse effects)
• Child, Preschool
• Eye Diseases (drug therapy, etiology)
• Female
• Hospitals, University
• Humans
• Male
• Nigeria
• Ophthalmic Solutions
• Stevens-Johnson Syndrome (complications, etiology, therapy)
• Trimethoprim, Sulfamethoxazole Drug Combination (adverse effects)