[Comparison of olopatadin and ketotifen in the treatment of allergic conjunctivitis].

To compare the efficacy of olopatadine 0.1 % and ketotifen 0.025 % ophthalmic solutions in the treatment of allergic conjunctivitis.
Forty patients with allergic conjunctivitis were included in the study, they were randomized in two groups: G-I (n = 20) olopatadine 0.1 % and G-II (n = 20) ketotifen 0.025 %, both receiving one drop every 12 hours. We evaluated itching, burning, tearing, redness and chemosis previously and 30 minutes, one, two and four week after.
Age G-I was 19.7 +/- 6.7 years; G-II, 21.05 +/- 8.3 years. When evaluating itching, olopatadine had a significant improvement at 30 minutes and after one week (p < 0.05). In the following weeks, the results were similar in both groups. Olopatadine showed significant improvement in burning at 30 minutes, one and two week (p < 0.05). Tearing significantly decreased at 30 minutes with olopatadine (p < 0.05). There was no difference in redness or chemosis improvement in both groups.
In this study, olopatadine 0.1 % was more effective than topical ketotifen 0.025 % in improving itching, tearing and burning in allergic conjunctivitis patients.
AuthorsMassiel Elena Varguez-Rodríguez, Adriana Hernández-López, Rocío de Los Angeles Gómez-Dávila
JournalRevista meĢdica del Instituto Mexicano del Seguro Social (Rev Med Inst Mex Seguro Soc) 2009 Jul-Aug Vol. 47 Issue 4 Pg. 399-404 ISSN: 0443-5117 [Print] Mexico
Vernacular TitleOlopatadina y ketotifeno para tratar conjuntivitis alérgica.
PMID20553645 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Allergic Agents
  • Dibenzoxepins
  • Olopatadine Hydrochloride
  • Ketotifen
  • Anti-Allergic Agents (therapeutic use)
  • Conjunctivitis, Allergic (drug therapy)
  • Dibenzoxepins (therapeutic use)
  • Female
  • Humans
  • Ketotifen (therapeutic use)
  • Male
  • Olopatadine Hydrochloride
  • Young Adult

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