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Automated heart-type fatty acid-binding protein assay for the early diagnosis of acute myocardial infarction.

Abstract
We compared an automated quantitative heart-type fatty acid-binding protein (H-FABP) assay with other cardiac-marker assays to examine its usefulness as an early diagnostic marker of acute myocardial infarction (AMI). Serum samples for cardiac troponin T (cTnT), creatine kinase-MB isozyme (CK-MB), myoglobin, and H-FABP were obtained from 64 patients with AMI and 53 patients with other conditions (control group). H-FABP was measured by using 2 immunoassays, the H-FABP enzyme-linked immunosorbent assay (ELISA; Biocheck, Foster City, CA) and the H-FABP latex turbidimetric immunoassay (LTIA; HBI, Anyang, Korea). Sensitivities of assays for cTnT, CK-MB, myoglobin, H-FABP (by ELISA), H-FABP (by LTIA), and electrocardiogram (ECG) for the diagnosis of AMI at hospital admission were 39.1%, 59.4%, 64.1%, 68.7%, 70.3%, and 54.7%, respectively. Specificities of cTnT, CK-MB, myoglobin, H-FABP (by ELISA), H-FABP (by LTIA), and ECG were 98.1%, 71.7%, 81.1%, 77.4%, 90.6%, and 92.5%, respectively. The automated H-FABP (by LTIA) is superior to cTnT, CK-MB, myoglobin, and H-FABP (by ELISA) tests for the diagnosis of AMI in patients admitted within 4 hours from the onset of chest pain.
AuthorsYeongsic Kim, Hyunjung Kim, Soo-Young Kim, Hae Kyung Lee, Hi Jeong Kwon, Yong Goo Kim, Jehoon Lee, Hyung Min Kim, Byung Hak So
JournalAmerican journal of clinical pathology (Am J Clin Pathol) Vol. 134 Issue 1 Pg. 157-62 (Jul 2010) ISSN: 1943-7722 [Electronic] United States
PMID20551280 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • FABP3 protein, human
  • Fatty Acid-Binding Proteins
  • Latex
  • Myoglobin
  • Troponin T
Topics
  • Chest Pain (blood, diagnosis, physiopathology)
  • Early Diagnosis
  • Electrocardiography
  • Fatty Acid-Binding Proteins (blood)
  • Female
  • Humans
  • Immunoassay (methods)
  • Latex
  • Male
  • Middle Aged
  • Myocardial Infarction (blood, diagnosis, physiopathology)
  • Myoglobin (blood)
  • Nephelometry and Turbidimetry (methods)
  • Predictive Value of Tests
  • ROC Curve
  • Time Factors
  • Troponin T (blood)

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