Abstract | OBJECTIVE: METHODS: RESULTS: The DAI, and macroscopic and histological changes in the BWXLS group were improved as compared with those in the untreated group (P<0.05) but were similar to those in the hydrocortisone group. The expression of occludin was significantly increased (P<0.05) while the expressions of TLR4, NF-kappaB and TNF-alpha were significantly decreased in the BWXLS group as compared with the untreated group, and were similar to those in the hydrocortisone group (P>0.05). CONCLUSION: Up-regulating the expression of occludin and down-regulating the expressions of TLR4 and NF-kappaB, and hence inhibiting TNF-alpha expression and improving the mucosa barrier function may be part of the mechanisms of BWXLS in treating oxazolone-induced colitis in mice.
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Authors | Yan Pan, Qin Ouyang |
Journal | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
(Zhong Xi Yi Jie He Xue Bao)
Vol. 8
Issue 6
Pg. 568-74
(Jun 2010)
ISSN: 1672-1977 [Print] China |
PMID | 20550880
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- Membrane Proteins
- NF-kappa B
- Occludin
- Ocln protein, mouse
- Tlr4 protein, mouse
- Toll-Like Receptor 4
- Tumor Necrosis Factor-alpha
- ba-wei-xi-lei
- Oxazolone
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Topics |
- Animals
- Colitis
(chemically induced, drug therapy)
- Drugs, Chinese Herbal
(therapeutic use)
- Male
- Membrane Proteins
(metabolism)
- Mice
- Mice, Inbred BALB C
- NF-kappa B
(metabolism)
- Occludin
- Oxazolone
(adverse effects)
- Toll-Like Receptor 4
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
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