[Study of visual acuity and intraocular pressure in the treatment of macular diabetic edema with intravitreous triamcinolone].

Abstract

PURPOSE:

To evaluate the effect of intravitreal triamcinolone acetonide in patients with diffuse diabetic macular edema on the visual acuity and intraocular pressure. To report the potential adverse events and to analyze the potential relationship between age and visual acuity and intraocular pressure variability.

METHODS:

This clinical controlled study included 14 patients (28 eyes), 14 of the eyes received an intravitreal injection of 4 mg triamcinolone acetonide for the treatment of diabetic macular edema. The study group was compared to a control group of 14 eyes, without diabetic macular edema. The follow-up period was of 3 months.

RESULTS:

Pressure spikes >21 mmHg occurred in 28.7% of eyes, with a significant difference of intraocular pressure between the study group and the control group in the first week after treatment. Visual acuity showed a significant improvement when compared with the control group since the second day after the treatment. There was no association between age and variability of visual acuity and intraocular pressure.

CONCLUSION:

Intravitreal triamcinolone acetonide showed to be effective for improving visual acuity in patients with diabetic macular edema, in the first three months of treatment. The incidence of intraocular hypertension was 28.7%, easily manageable.

• Authors: Marcussi Palata Rezende, Alana Ferreira Gomes Dias, Akiyoshi Oshima, Eric Pinheiro de Andrade, Pedro Durães Serracarbassa
• Journal: Arquivos brasileiros de oftalmologia (Arq Bras Oftalmol) 2010 Mar-Apr Vol. 73 Issue 2 Pg. 129-34 ISSN: 1678-2925 [Electronic] Brazil
• Vernacular Title: Avaliação da acuidade visual e da pressão intraocular no tratamento do edema macular diabético com triancinolona intravítrea.
• PMID: 20549040 (Publication Type: Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Triamcinolone Acetonide

Topics

• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents (administration & dosage, adverse effects)
• Case-Control Studies
• Diabetic Retinopathy (complications, drug therapy)
• Female
• Follow-Up Studies
• Humans
• Intraocular Pressure (drug effects)
• Macular Edema (drug therapy, etiology)
• Male
• Middle Aged
• Triamcinolone Acetonide (administration & dosage, adverse effects)
• Visual Acuity (drug effects)
• Vitreous Body