Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.

Abstract

The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.

• Authors: M R Sulaiman, E K Perimal, M N Akhtar, A S Mohamad, M H Khalid, N A Tasrip, F Mokhtar, Z A Zakaria, N H Lajis, D A Israf
• Journal: Fitoterapia (Fitoterapia) Vol. 81 Issue 7 Pg. 855-8 (Oct 2010) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 20546845 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Plant Extracts
• Sesquiterpenes
• zerumbone
• Carrageenan

Topics

• Animals
• Anti-Inflammatory Agents (administration & dosage, pharmacology, therapeutic use)
• Carrageenan
• Disease Models, Animal
• Edema (chemically induced, drug therapy)
• Gossypium
• Granuloma (chemically induced, drug therapy)
• Inflammation (chemically induced, drug therapy)
• Male
• Mice
• Mice, Inbred ICR
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)
• Rhizome
• Sesquiterpenes (administration & dosage, pharmacology, therapeutic use)
• Zingiberaceae (chemistry)