The macrophage stimulating protein/Ron pathway as a potential therapeutic target to impede multiple mechanisms involved in breast cancer progression.

Abstract

Macrophage Stimulating Protein (MSP) is the only known ligand for the receptor tyrosine kinase Ron. The MSP/Ron pathway is involved in several important biological processes, including macrophage activity, wound healing, and epithelial cell behavior. A role for MSP/Ron in breast cancer has recently been elucidated, wherein this pathway regulates tumor growth, angiogenesis, and metastasis. Here, we review the recent literature surrounding MSP/Ron function in tumor cells, inflammatory cells, and osteoclasts - cell types that often coexist in breast tumor microenvironments. We discuss the potential implications of MSP/Ron activity occurring concurrently in these cell types on tumor progression and metastasis. Lastly, we outline the potential for targeting MSP/Ron as a novel therapy for breast cancer, and for other cancer types.

• Authors: Kelsi L Kretschmann, Henok Eyob, Saundra S Buys, Alana L Welm
• Journal: Current drug targets (Curr Drug Targets) Vol. 11 Issue 9 Pg. 1157-68 (Sep 2010) ISSN: 1873-5592 [Electronic] United Arab Emirates
• PMID: 20545605 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Proto-Oncogene Proteins
• macrophage stimulating protein
• Hepatocyte Growth Factor
• RON protein
• Receptor Protein-Tyrosine Kinases

Topics

• Animals
• Breast Neoplasms (drug therapy, metabolism, physiopathology)
• Cell Line, Tumor
• Disease Progression
• Epithelial Cells (metabolism)
• Female
• Hepatocyte Growth Factor (metabolism)
• Humans
• Inflammation (physiopathology)
• Macrophages (physiology)
• Mice
• Mice, Transgenic
• Molecular Targeted Therapy
• Neoplasms (drug therapy, metabolism)
• Osteoclasts (metabolism)
• Proto-Oncogene Proteins (metabolism)
• Receptor Protein-Tyrosine Kinases (antagonists & inhibitors, metabolism)
• Signal Transduction
• Wound Healing