Protection of mouse heart against hypoxic damage by AMP deaminase inhibition.

Abstract

Clinical observation in patients with heart disease indicates that reduced activity of AMP deaminase could be protective in heart failure and ischemic heart disease. This study evaluated the effect of 3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo [4,5-d][1,3]diazepin-8-ol, an AMP deaminase inhibitor (AMPDI) in the mouse heart subjected to hypoxia. ApoE/LDLR knock-out mice were subjected to reduced oxygen tension in breathing air. AMPDI was infused before hypoxia in the treated group. We observed amelioration of elcetrocardiographic changes during hypoxia in the treated group that are consistent with a protective effect.

• Authors: T Borkowski, E M Slominska, C Orlewska, S Chlopicki, P Siondalski, M H Yacoub, R T Smolenski
• Journal: Nucleosides, nucleotides & nucleic acids (Nucleosides Nucleotides Nucleic Acids) Vol. 29 Issue 4-6 Pg. 449-52 (Jun 2010) ISSN: 1532-2335 [Electronic] United States
• PMID: 20544535 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Enzyme Inhibitors
• AMP Deaminase

Topics

• AMP Deaminase (antagonists & inhibitors)
• Animals
• Enzyme Inhibitors (therapeutic use)
• Hypoxia (drug therapy)
• Mice
• Mice, Knockout