Abstract | AIM: PATIENTS AND METHOD: The study included 66 adult renal transplantation recipients. We recorded the parameters of venous blood gas analysis including serum pH value, serum bicarbonate (HCO(3)) concentration, presence of metabolic acidosis, which was defined as low HCO(3) (<22 mEq/L), and serum pH value (<7.35) together, and base excess and urine pH at the last follow-up. Creatinine clearance was determined from 24-hour collected urine samples. RTA was defined to be metabolic acidosis with normal serum anion gap and positive urine anion gap. RESULTS: Mean age of 66 patients was 37.0 +/- 10.4 years; 48 of 66 patients were male. RTA was found in 14 (21.2%) patients. Considering for differential diagnosis of RTA, 4 patients had type 2 RTA and 10 had type 1 RTA. On the contrary, type 4 RTA was observed in no patients. Creatinine clearance was meaningfully lower in acidosis group than in those of the nonacidosis group (55.16 +/- 23.27 vs. 71.06 +/- 28.14 mL/min; p = 0.028). HCO(3) was correlated with hemoglobin level (r = 0.423, p = 0.001) and creatinine clearance (r = 0.262, p = 0.034). It was inversely correlated with cyclosporine A (CsA) level (r = -0.499, p = 0.035). CONCLUSION:
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Authors | Ismail Kocyigit, Aydin Unal, Feridun Kavuncuoglu, Murat Hayri Sipahioglu, Bulent Tokgoz, Oktay Oymak, Cengiz Utas |
Journal | Renal failure
(Ren Fail)
Vol. 32
Issue 6
Pg. 687-90
(Jul 2010)
ISSN: 1525-6049 [Electronic] England |
PMID | 20540636
(Publication Type: Journal Article)
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Topics |
- Acidosis, Renal Tubular
(epidemiology, etiology)
- Adult
- Female
- Humans
- Kidney Transplantation
(adverse effects)
- Male
- Prevalence
- Risk Factors
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