Clinical experience with N-butyl cyanoacrylate tissue adhesive in corneal perforations secondary to herpetic keratitis.

Abstract

PURPOSE:

To evaluate the success of cyanoacrylate tissue adhesive in the management of corneal perforations associated with herpetic keratitis.

METHODS:

Case records of 46 patients with microbiologically proven herpetic keratitis associated with corneal perforations that were treated with corneal gluing were analyzed retrospectively in a tertiary care hospital. N-Butyl cyanoacrylate tissue adhesive and bandage contact lens were applied in addition to antiviral therapy. The main outcome measure was preservation of the structural integrity of the globe.

RESULTS:

Glue application could heal corneal perforations in only 17 eyes (37%). Therapeutic keratoplasty had to be performed in 26 eyes (57%) because of failure of the glue. Fourteen eyes (31%) required multiple applications of tissue adhesive, and 2 eyes had to be eviscerated. Location of perforation, additional anterior chamber intervention, and use of prophylactic acyclovir therapy had no statistically significant effect on the overall final outcome.

CONCLUSION:

Corneal perforations associated with herpetic keratitis may not heal with glue application alone, and corneal transplantation surgery may be required to maintain the ocular structural integrity.

• Authors: Sonia Moorthy, Vishal Jhanji, Marios Constantinou, Jacqueline Beltz, Enrique O Graue-Hernandez, Rasik B Vajpayee
• Journal: Cornea (Cornea) Vol. 29 Issue 9 Pg. 971-5 (Sep 2010) ISSN: 1536-4798 [Electronic] United States
• PMID: 20539218 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Tissue Adhesives
• Enbucrilate
• Acyclovir

Topics

• Acyclovir (therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Antiviral Agents (therapeutic use)
• Corneal Perforation (drug therapy, etiology)
• Enbucrilate (therapeutic use)
• Female
• Humans
• Keratitis, Herpetic (complications, drug therapy)
• Male
• Middle Aged
• Retrospective Studies
• Tissue Adhesives (therapeutic use)
• Treatment Outcome
• Wound Healing (drug effects)