Synthesis of an antitumor active endoperoxide from 11-keto-beta-boswellic acid.

Abstract	An endoperoxide was synthesized starting from 11-keto-beta-boswellic acid and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The compound induces apoptosis and shows an average IC(50) value of 0.4-4.5 microM.
Authors	René Csuk, Anja Niesen-Barthel, Alexander Barthel, Ralph Kluge, Dieter Ströhl
Journal	European journal of medicinal chemistry (Eur J Med Chem) Vol. 45 Issue 9 Pg. 3840-3 (Sep 2010) ISSN: 1768-3254 [Electronic] France
PMID	20538386 (Publication Type: Journal Article)
Copyright	2010 Elsevier Masson SAS. All rights reserved.
Chemical References	11-keto-boswellic acid Antineoplastic Agents Triterpenes
Topics	Antineoplastic Agents (chemical synthesis, chemistry, pharmacology) Cell Line, Tumor Humans Inhibitory Concentration 50 Triterpenes (chemical synthesis, chemistry, pharmacology)

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