Inhibition of neointimal hyperplasia after stent placement with rhenium 188-filled balloon dilation in a canine iliac artery model.

Abstract

PURPOSE:

To evaluate the efficacy of beta-irradiation therapy with rhenium 188 ((188)Re) mercaptoacetyltriglycine (MAG3)-filled balloon dilation to prevent neointimal hyperplasia after stent placement in a canine iliac artery model.

MATERIALS AND METHODS:

A total of 15 stents were implanted into the iliac arteries of eight dogs (one or two stents in each dog). Rhenium 188 MAG3-filled balloon dilation was performed immediately after placement of 10 bare stents-20 Gy in group II (n = 5) and 40 Gy in group III (n = 5)-and conventional balloon dilation was performed immediately after placement of the remaining five bare stents (group I). A follow-up angiogram was obtained 8 weeks after the procedure, and percentage of luminal stenosis was calculated for the proximal and distal ends of each stent. Neointimal thickening (expressed as the neointimal area divided by the sum of neointimal area and media area) was assessed for microscopic examination.

RESULTS:

All eight dogs survived until they were euthanized 8 weeks after the procedures. The mean luminal stenosis measurements at 8-week follow-up angiography in groups I, II, and III were 26.63%, -0.44%, and 10.53%, respectively. The mean neointimal thickening measurements in groups I, II, and III were 0.77, 0.21, and 0.34, respectively. The mean percentage of luminal stenosis and neointimal thickening differed significantly among the three groups (P < .05).

CONCLUSIONS:

beta-Irradiation with (188)Re-MAG3-filled balloon dilation has the potential to reduce neointimal hyperplasia secondary to stent placement in a canine iliac artery model. A dose of 20 Gy may be preferable versus a dose of 40 Gy to reduce neointimal hyperplasia.

• Authors: Tae-Hyung Kim, Ji Hoon Shin, Seung-Jun Oh, In Kook Park, Chul-Woong Woo, Kyung Hee Han, Kyung-Rae Dong
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 21 Issue 7 Pg. 1066-70 (Jul 2010) ISSN: 1535-7732 [Electronic] United States
• PMID: 20537913 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved.

Chemical References

• Isotopes
• Radiopharmaceuticals
• Rhenium

Topics

• Animals
• Blood Vessel Prosthesis (adverse effects)
• Catheterization (methods)
• Disease Models, Animal
• Dogs
• Graft Occlusion, Vascular (etiology, radiotherapy)
• Humans
• Iliac Artery (radiation effects, surgery)
• Isotopes (therapeutic use)
• Radiopharmaceuticals (therapeutic use)
• Rhenium (therapeutic use)
• Stents (adverse effects)
• Treatment Outcome