HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

[Antitumor activity and toxicity of KB-5424 R, a newly developed antitumor platinum compound].

Abstract
KB-5424 (ab-(3-aminopyrrolidine)-cd-[glycolato (2-)-0, 0'] platinum (II) is a newly developed antitumor platinum compound which was synthesized at Kanebo Institute for Cancer Research. When the antitumor activity of KB-5424 was evaluated using several rodent tumors, no significant differences were observed between the antitumor activities of KB-5424, cisplatin (CDDP) and DWA-2114 R (DWA). KB-5424 was divided into two kinds of optical isomers, KB-5424 R and KB-5424 S, of which antitumor activity was compared each other. The maximum increased life span (ILSmax) on L 1210 of KB-5424 R was almost equal to that of CDDP and better than those of KB-5424 S and carboplatin (CBDCA). The antitumor activity of KB-5424 R on a human tumor xenograft MX-1 was almost identical to those of CDDP and CBDCA and better than that of DWA. Since the nephrotoxicity of KB-5424 R was significantly reduced comparing with CDDP, this newly developed antitumor platinum compound was thought to be a promising agent for the clinical application.
AuthorsH Yamaguchi, T Kubota, T Takahara, T Takeuchi, T Furukawa, S Kase, K Josui, S Kodaira, K Ishibiki, O Abe
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 18 Issue 7 Pg. 1135-41 (Jun 1991) ISSN: 0385-0684 [Print] JAPAN
PMID2053772 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Organoplatinum Compounds
  • DWA 2114
  • KB 5424
  • Carboplatin
  • Cisplatin
Topics
  • Animals
  • Antineoplastic Agents (adverse effects, chemistry, therapeutic use)
  • Carboplatin (analogs & derivatives, therapeutic use)
  • Cisplatin (therapeutic use)
  • Drug Screening Assays, Antitumor
  • Kidney (drug effects)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Neoplasm Transplantation
  • Neoplasms, Experimental (drug therapy)
  • Optical Rotation
  • Organoplatinum Compounds (administration & dosage, therapeutic use)
  • Rats
  • Rats, Inbred F344

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: