Abstract | OBJECTIVE: To compare patterns of luteal phase bleeding (LPB) in IVF cycles supplemented with Crinone and with intramuscular progesterone ( IMP) and to evaluate the impact of luteal estrogen supplementation on LPB. DESIGN: Prospective, randomized trial and post hoc analysis. SETTING: University-affiliated IVF unit. PATIENT(S): Women under age 40 with day 3 FSH <15 mIU/mL were randomized to receive either Crinone or IMP for luteal phase support. Luteal estrogen was prescribed according to clinical protocols. Three hundred sixty-five patients were queried about LPB after completion of their IVF cycles. INTERVENTION(S): MAIN OUTCOME MEASURE(S): Incidence of LPB in IVF cycles supplemented with Crinone and IMP and impact of luteal estrogen on the occurrence of LPB. RESULT(S): There was no difference in the overall incidence of LPB between patients treated with Crinone and those treated with IMP (33.2% vs. 25.7%). LPB occurred with equal frequency among pregnant patients in both arms ( Crinone 21.9% vs. IMP 18.6%). Only nonpregnant women had a higher incidence of LPB when treated with Crinone compared with treatment with IMP (56.5% vs.38.1%). Estrogen supplementation decreased the occurrence of LPB among all participants but did not impact pregnancy rates. CONCLUSION(S): Only nonpregnant women had a higher incidence of bleeding in the luteal phase when supplemented with Crinone compared with treatment with IMP. IMP delays menses in nonpregnant cycles without affecting pregnancy rates. Luteal estrogen decreases LPB without impacting cycle outcomes.
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Authors | Elena Yanushpolsky, Shelley Hurwitz, Louise Greenberg, Catherine Racowsky, Mark Hornstein |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 95
Issue 2
Pg. 617-20
(Feb 2011)
ISSN: 1556-5653 [Electronic] United States |
PMID | 20537624
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Crinone
- Vaginal Creams, Foams, and Jellies
- Progesterone
- Estradiol
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Topics |
- Adult
- Estradiol
(blood)
- Female
- Fertilization in Vitro
(adverse effects, methods)
- Humans
- Incidence
- Injections, Intramuscular
- Luteal Phase
(blood, drug effects, physiology)
- Pregnancy
- Pregnancy Rate
- Progesterone
(administration & dosage, adverse effects, analogs & derivatives)
- Uterine Hemorrhage
(chemically induced, epidemiology)
- Vaginal Creams, Foams, and Jellies
(administration & dosage, adverse effects)
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