Fluoroquinolone resistance in campylobacter.

Campylobacter is a commensal in poultry, and therefore, poultry and poultry products are major sources of Campylobacter infections in humans. Fluoroquinolones inhibit the growth of Campylobacter and other microorganisms by binding to bacterial DNA gyrase and DNA topoisomerase IV. These enzymes are associated with bacterial transcription, replication, and chromosome condensation and segregation. Selection pressure in the presence of fluoroquinolones rapidly leads to resistance in Campylobacter, due to the selection for mutations in DNA gyrase. Fluoroquinolone-resistant campylobacters have been found in poultry feces and carcasses, and in retail poultry meat products in most areas of the world. In addition, other food animals and the meat products from those animals have been shown contaminated with fluoroquinolone-resistant campylobacters. Even the removal of fluoroquinolones from use in treating animal diseases has not entirely eliminated the presence of resistant Campylobacter jejuni and Campylobacter coli from animals and animal products. Human exposure to Campylobacter infection could be reduced by using strategies that decrease colonization of chickens by the pathogen.
AuthorsJames L Smith, Pina M Fratamico
JournalJournal of food protection (J Food Prot) Vol. 73 Issue 6 Pg. 1141-52 (Jun 2010) ISSN: 0362-028X [Print] United States
PMID20537275 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Bacterial Agents
  • Fluoroquinolones
  • DNA Topoisomerases, Type I
  • DNA Gyrase
  • Animals
  • Anti-Bacterial Agents (pharmacology)
  • Campylobacter (drug effects, enzymology)
  • Campylobacter Infections (drug therapy, microbiology)
  • Chickens (microbiology)
  • DNA Gyrase (genetics)
  • DNA Topoisomerases, Type I (genetics)
  • Drug Resistance, Bacterial
  • Fluoroquinolones (pharmacology)
  • Food Microbiology
  • Humans
  • Microbial Sensitivity Tests
  • Poultry Diseases (drug therapy, microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: