Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes.

Abstract

Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following diets for 5 weeks: 15 % soybean oil (control group); 15 % palm oil (PO); and 15 % PO with the addition of 5.25 g gamma-oryzanol (POO). The results showed that PO markedly increased plasma low-density-lipoprotein cholesterol, plasma triglycerides, and hepatic triglyceride levels, but did not reduce the area under the curve for glucose and insulin significantly, compared with the control group. Adding gamma-oryzanol to PO improved the negative influence of PO on lipid metabolism in T2DM rats. In addition, gamma-oryzanol tended to increase insulin sensitivity in T2DM rats compared to control and PO groups. Longer-term studies are needed to evaluate these effects further.

• Authors: Hsing-Hsien Cheng, Chien-Ya Ma, Tsui-Wei Chou, Ya-Yen Chen, Ming-Hoang Lai
• Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition (Int J Vitam Nutr Res) Vol. 80 Issue 1 Pg. 45-53 (Jan 2010) ISSN: 0300-9831 [Print] Switzerland
• PMID: 20533244 (Publication Type: Journal Article)

Chemical References

• Bile Acids and Salts
• Hypoglycemic Agents
• Hypolipidemic Agents
• Lipoproteins
• Phenylpropionates
• Plant Oils
• Sterols
• Triglycerides
• lipoprotein cholesterol
• Palm Oil
• Cholesterol
• Rice Bran Oil
• gamma-oryzanol

Topics

• Animals
• Bile Acids and Salts (analysis)
• Cholesterol (blood)
• Diabetes Mellitus, Experimental (chemically induced, complications, drug therapy)
• Diabetes Mellitus, Type 2 (chemically induced, complications, drug therapy)
• Diet (adverse effects)
• Feces (chemistry)
• Glucose Tolerance Test
• Hyperlipidemias (chemically induced, prevention & control)
• Hypoglycemic Agents (therapeutic use)
• Hypolipidemic Agents (therapeutic use)
• Insulin Resistance
• Lipoproteins (blood)
• Liver (chemistry, drug effects)
• Male
• Palm Oil
• Phenylpropionates (therapeutic use)
• Plant Oils (chemistry, toxicity)
• Rats
• Rats, Wistar
• Rice Bran Oil
• Sterols (analysis)
• Triglycerides (analysis, blood)