Comparison of 7- and 14-day first-line therapies including levofloxacin in patients with Helicobacter pylori positive non-ulcer dyspepsia.

Abstract

BACKGROUND/AIMS:

Because of the increasing resistance to clarithromycin and metronidazole, the most frequently used antibiotics in the first-line therapy of Helicobacter pylori eradication, new therapeutic alternatives are needed. The aim of this study was to compare the efficacy of 7- and 14-day triple therapy including lansoprazole, levofloxacin and amoxicillin for Helicobacter pylori eradication as a first-line therapy.

METHODS:

Ninety-one non-ulcer dyspeptic patients infected with Helicobacter pylori as diagnosed by both histology and a rapid urease test were included in this study. Patients were randomized to receive either 7- (Group 1; 51 patients) or 14-day (Group 2; 40 patients) therapy with lansoprazole (30 mg b.i.d.), plus levofloxacin (500 mg o.i.d.) and amoxicillin (1000 mg b.i.d.) and they were followed for six weeks. Eradication was assessed by 14C-urea breath test four weeks after completing the treatment protocols.

RESULTS:

In Group 1, 41 patients completed the treatment and the eradication rate was 34.15%. In group 2, 36 patients completed the treatment and the eradication rate was 72.2% (p= 0.001 vs group 1).

CONCLUSIONS:

Triple therapy with lansoprazole, levofloxacin and amoxicillin for 14 days was effective for Helicobacter pylori eradication, but 7-day therapy with the same protocol had a lower and unacceptable cure rate and should not be used.

• Authors: Cemal Nuri Erçin, Ahmet Uygun, Ahmet Burak Toros, Murat Kantarcioğlu, Güldem Kilciler, Zülfikar Polat, Sait Bağci
• Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (Turk J Gastroenterol) Vol. 21 Issue 1 Pg. 12-6 (Mar 2010) ISSN: 2148-5607 [Electronic] Turkey
• PMID: 20533106 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Bacterial Agents
• Anti-Infective Agents
• Lansoprazole
• Levofloxacin
• Amoxicillin
• Ofloxacin

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles (administration & dosage)
• Adult
• Amoxicillin (administration & dosage)
• Anti-Bacterial Agents (administration & dosage)
• Anti-Infective Agents (administration & dosage)
• Breath Tests
• Drug Therapy, Combination
• Dyspepsia (drug therapy)
• Female
• Helicobacter Infections (drug therapy)
• Helicobacter pylori
• Humans
• Lansoprazole
• Levofloxacin
• Male
• Middle Aged
• Ofloxacin (administration & dosage)