Abstract | BACKGROUND: To investigate the distribution of CCR5-Delta32, CCR2-64I, and SDF1-3'A alleles in Guangxi province Zhuang population. METHOD: A total of 180 healthy individuals and 150 HIV-positive patients were recruited. All individuals were genotyped for CCR5 polymorphism using polymerase chain reaction (PCR), and CCR2 and SDF1 polymorphism using PCR restriction fragment length polymorphisms (PCR-RFLPs). RESULTS: No CCR5-Delta32 mutation was found. CCR2-64I frequency was 24.7% in the healthy group and 20.3% in the HIV-positive group, and SDF1-3'A was 30.6% and 29.3% in the 2 groups, respectively. There were no significances in the frequencies of CCR2-64I (chi(2) = 1.795, P = .180) and SDF1-3'A (chi(2) = 0.116, P = .733) between the 2 groups. CONCLUSIONS: The protective CCR5-Delta32 mutation is absent in the Zhuang population, but CCR2-64I and SDF1-3'A are relatively common and seem not to confer protection against HIV-1 infection. The results suggest that the Zhuang people may have a similar genetic susceptibility to HIV-1 infection with most other Chinese ethnic groups.
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Authors | Qijian Su, Zhidan Mai, Ning Zang, Shuzhi Wu, Xin Xiao, Hao Liang |
Journal | Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)
(J Int Assoc Physicians AIDS Care (Chic))
2010 May-Jun
Vol. 9
Issue 3
Pg. 145-9
ISSN: 1545-1097 [Print] United States |
PMID | 20530467
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CCR2 protein, human
- Chemokine CXCL12
- Receptors, CCR2
- Receptors, CCR5
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Topics |
- Adolescent
- Adult
- Case-Control Studies
- Chemokine CXCL12
(genetics)
- China
(epidemiology)
- Female
- Gene Frequency
- Genotype
- HIV Infections
(epidemiology, genetics)
- Heterozygote
- Homozygote
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, CCR2
(genetics)
- Receptors, CCR5
(genetics)
- Young Adult
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