Abstract | AIM: PATIENTS AND METHODS: STK1 was determined before and within one week after surgery of carcinoma patients (non-small cell lung (NSCLC), n=25, oesophagueal, n=12, cardial, n=4,) by a chemiluminescent dot blot assay using anti-TK1 IgY antibody. RESULTS: The mean age of the patients with high STK1 values after surgery was 63.2+/-8.7 years, while that for patients with stable/low STK1 values was 54.8+/-11.8 years; this was significantly different at P<0.05. Sixty-one percent of the patients with high STK1 values after surgery exhibited declining red blood cell (35%) or increasing white blood cell/neutrophil cell (29%) counts. The high STK1 values after surgery correlated with a prolonged operation execution time in anaemic patients (3.43+/-0.90 h), as compared non-anaemic patients (2.72+/-0.79 h). The high STK1 values also correlated with extensive surgery programs (oseophageal/ cardial carcinoma, 3.31+/-0.70 h, versus NSCLC, 2.44+/-0.63 h). CONCLUSION: The transiently elevated STK1 values post-operation might be due to surgery-induced complications, such as anaemia and infection/ inflammation, but also to operation execution times and age of patients. We suggest that STK1 should not be used within one week post-operation, but before surgery and after one month to avoid non- tumor-related increases in STK1, and thus misleading results.
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Authors | Zhishan Li, Yinghong Wang, Jie Ma, Jie He, Ji Zhou, Ellen He, Sven Skog |
Journal | Anticancer research
(Anticancer Res)
Vol. 30
Issue 4
Pg. 1295-9
(Apr 2010)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 20530443
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Thymidine Kinase
- thymidine kinase 1
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Topics |
- Age Factors
- Carcinoma
(blood, enzymology, surgery)
- Carcinoma, Non-Small-Cell Lung
(blood, enzymology, surgery)
- Erythrocyte Count
- Esophageal Neoplasms
(blood, enzymology, surgery)
- Female
- Humans
- Leukocyte Count
- Lung Neoplasms
(blood, enzymology, surgery)
- Male
- Middle Aged
- Neoplasms
(blood, enzymology, surgery)
- Stomach Neoplasms
(blood, enzymology, surgery)
- Thymidine Kinase
(blood)
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