Transient increase in serum thymidine kinase 1 within one week after surgery of patients with carcinoma.

To investigate transient increases of thymidine kinase 1 in serum (STK1) after surgery of patients with carcinoma.
STK1 was determined before and within one week after surgery of carcinoma patients (non-small cell lung (NSCLC), n=25, oesophagueal, n=12, cardial, n=4,) by a chemiluminescent dot blot assay using anti-TK1 IgY antibody.
The mean age of the patients with high STK1 values after surgery was 63.2+/-8.7 years, while that for patients with stable/low STK1 values was 54.8+/-11.8 years; this was significantly different at P<0.05. Sixty-one percent of the patients with high STK1 values after surgery exhibited declining red blood cell (35%) or increasing white blood cell/neutrophil cell (29%) counts. The high STK1 values after surgery correlated with a prolonged operation execution time in anaemic patients (3.43+/-0.90 h), as compared non-anaemic patients (2.72+/-0.79 h). The high STK1 values also correlated with extensive surgery programs (oseophageal/ cardial carcinoma, 3.31+/-0.70 h, versus NSCLC, 2.44+/-0.63 h).
The transiently elevated STK1 values post-operation might be due to surgery-induced complications, such as anaemia and infection/inflammation, but also to operation execution times and age of patients. We suggest that STK1 should not be used within one week post-operation, but before surgery and after one month to avoid non-tumor-related increases in STK1, and thus misleading results.
AuthorsZhishan Li, Yinghong Wang, Jie Ma, Jie He, Ji Zhou, Ellen He, Sven Skog
JournalAnticancer research (Anticancer Res) Vol. 30 Issue 4 Pg. 1295-9 (Apr 2010) ISSN: 1791-7530 [Electronic] Greece
PMID20530443 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Thymidine Kinase
  • thymidine kinase 1
  • Age Factors
  • Carcinoma (blood, enzymology, surgery)
  • Carcinoma, Non-Small-Cell Lung (blood, enzymology, surgery)
  • Erythrocyte Count
  • Esophageal Neoplasms (blood, enzymology, surgery)
  • Female
  • Humans
  • Leukocyte Count
  • Lung Neoplasms (blood, enzymology, surgery)
  • Male
  • Middle Aged
  • Neoplasms (blood, enzymology, surgery)
  • Stomach Neoplasms (blood, enzymology, surgery)
  • Thymidine Kinase (blood)

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