Aqueous humor and plasma levels of vascular endothelial growth factor and interleukin-8 in patients with central serous chorioretinopathy.

Abstract

PURPOSE:

The purpose of this study was to determine aqueous vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) levels in patients with central serous chori-oretinopathy (CSC) before a single intravitreal bevacizumab injection.

METHODS:

Twelve eyes with symptomatic CSC were included. Samples from patients with cataracts served as controls. The levels of VEGF and IL-8 concentrations were measured in aqueous humor and plasma by multiplex bead assays.

RESULTS:

All patients with CSC showed an improvement in visual acuity and resolved neurosensory detachment after intravitreal bevacizumab injection. The aqueous humor levels of VEGF and IL-8 were not significantly increased in patients with CSC compared with the healthy control group (18.2 ± 24.8 vs. 35.3 ± 28.5 pg/mL, P > 0.05; 2.3 ± 0.4 vs. 2.8 ± 0.3 pg/mL, P > 0.05, respectively). The plasma levels of VEGF and IL-8 in patients with CSC were not different from those in the healthy control group.

CONCLUSION:

Vascular endothelial growth factor and IL-8 were not increased in the aqueous humor and plasma of patients with CSC. The effect of intravitreal bevacizumab injection as a treatment for CSC must be fully understood, and the true effect of anti-VEGF treatment in patients with CSC remains to be elucidated.

• Authors: Ji Won Lim, Min Uk Kim, Min-Cheol Shin
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 30 Issue 9 Pg. 1465-71 (Oct 2010) ISSN: 1539-2864 [Electronic] United States
• PMID: 20526231 (Publication Type: Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Coloring Agents
• Interleukin-8
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Bevacizumab
• Indocyanine Green

Topics

• Adult
• Aged
• Angiogenesis Inhibitors (administration & dosage)
• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Humanized
• Aqueous Humor (metabolism)
• Bevacizumab
• Central Serous Chorioretinopathy (blood, diagnosis, drug therapy)
• Coloring Agents
• Female
• Fluorescein Angiography
• Humans
• Indocyanine Green
• Interleukin-8 (blood)
• Intravitreal Injections
• Male
• Middle Aged
• Prospective Studies
• Tomography, Optical Coherence
• Vascular Endothelial Growth Factor A (blood)
• Visual Acuity (physiology)