Abstract | INTRODUCTION: Radical prostatectomy is the treatment of choice for prostate cancer patients. Despite the introduction of nerve-sparing surgical techniques, its success is not entirely guaranteed and the majority of patients report compromised erectile function following surgical procedures. AIM: METHODS: Thirty male Sprague-Dawley rats (300-320 g) were used in this study. The animals were divided into three groups; group I consisted of sham-operated animals (N = 10), animals in group II underwent BCNR alone (N = 10), and animals in group III were orally treated with 10 mg/kg udenafil b.i.d. for 8 weeks following BCNR (N = 10). MAIN OUTCOME MEASURES: RESULTS: While fibrosis, apoptosis, and the expression of TGF-beta1, HIF-1 alpha, and ET(B) were significantly increased, and the expression of eNOS and nNOS were significantly decreased in group II, compared with the sham-operated animals, repeated dosing of udenafil significantly ameliorated these changes. Erectile function was profoundly impaired in animals that underwent BCNR alone, and udenafil treatment significantly attenuated this impairment as measured by ICP. CONCLUSIONS: These results demonstrate that long-term administration of udenafil ameliorates penile hypoxia and fibrosis induced by cavernous nerve resection. This study also suggests the potential beneficial role of repeated dosing of udenafil in the recovery of erectile function in patients with neuronal erectile dysfunction.
|
Authors | Chan-Ho Lee, Jee-Hyun Shin, Gook-Jun Ahn, Kyung-Koo Kang, Byoung-Ok Ahn, Moohi Yoo |
Journal | The journal of sexual medicine
(J Sex Med)
Vol. 7
Issue 7
Pg. 2564-71
(Jul 2010)
ISSN: 1743-6109 [Electronic] Netherlands |
PMID | 20524975
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Pyrimidines
- Sulfonamides
- RNA
- udenafil
|
Topics |
- Analysis of Variance
- Animals
- Apoptosis
(drug effects)
- Fibrosis
- Impotence, Vasculogenic
(drug therapy, etiology, physiopathology)
- Male
- Penile Erection
(drug effects)
- Postoperative Complications
(drug therapy, etiology)
- Pyrimidines
(therapeutic use)
- RNA
- Rats
- Rats, Sprague-Dawley
- Reverse Transcriptase Polymerase Chain Reaction
- Statistics, Nonparametric
- Sulfonamides
(therapeutic use)
|