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Identification of a secondary FLT3/A848P mutation in a patient with FLT3-ITD-positive blast phase CMML and response to sunitinib and sorafenib.

AuthorsN von Bubnoff, C Rummelt, H Menzel, M Sigl, C Peschel, J Duyster
JournalLeukemia (Leukemia) Vol. 24 Issue 8 Pg. 1523-5 (Aug 2010) ISSN: 1476-5551 [Electronic] England
PMID20520641 (Publication Type: Case Reports, Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzenesulfonates
  • Indoles
  • Phenylurea Compounds
  • Pyridines
  • Pyrroles
  • Niacinamide
  • Sorafenib
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3
  • Sunitinib
Topics
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Benzenesulfonates (therapeutic use)
  • Female
  • Humans
  • Indoles (therapeutic use)
  • Leukemia, Myelomonocytic, Chronic (drug therapy, genetics)
  • Mutation
  • Niacinamide (analogs & derivatives)
  • Phenylurea Compounds
  • Pyridines (therapeutic use)
  • Pyrroles (therapeutic use)
  • Sorafenib
  • Sunitinib
  • fms-Like Tyrosine Kinase 3 (genetics)

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