Abstract | OBJECTIVE: STUDY DESIGN: Cell blocks of pancreatic fine needle aspirates from 19 ductal adenocarcinomas, 9 IPMNs, 5 MCNs, and 22 cases containing gastrointestinal epithelial contamination (GIC) (7 gastric, 15 duodenal) were stained with antibody to carcinoembryonic antigen (CEA) and B72.3. RESULTS: CEA was positive in 89% of adenocarcinomas and 92% of mucinous lesions. It was never expressed in gastric contamination and was positive in 2/15 (13%) duodenal contaminants. B72.3 was positive in 95% of adenocarcinomas and 85% of mucinous lesions. It was positive in 2/7 (28%) gastric and 7/15 (47%) duodenal contaminants. CONCLUSION: In contrast to previous work, our preliminary results indicate that B72.3 expression cannot be reliably used to identify GIC. A lack of CEA expression, however, can be used to identify both gastric and duodenal contamination. This represents an important diagnostic aid in the evaluation of suspected low grade mucinous lesions.
|
Authors | Adam D Toll, Marluce Bibbo |
Journal | Acta cytologica
(Acta Cytol)
2010 May-Jun
Vol. 54
Issue 3
Pg. 245-8
ISSN: 0001-5547 [Print] Switzerland |
PMID | 20518405
(Publication Type: Evaluation Study, Journal Article)
|
Chemical References |
- Antibodies, Neoplasm
- B72.3 antibody
- Biomarkers
- Carcinoembryonic Antigen
|
Topics |
- Adenocarcinoma, Mucinous
(diagnosis, metabolism)
- Antibodies, Neoplasm
(metabolism)
- Artifacts
- Biomarkers
(metabolism)
- Biopsy, Fine-Needle
- Carcinoembryonic Antigen
(metabolism)
- Carcinoma, Pancreatic Ductal
(diagnosis, metabolism)
- Carcinoma, Papillary
(diagnosis, metabolism)
- Diagnostic Errors
(prevention & control)
- Duodenum
(metabolism, pathology)
- Endosonography
- Gastric Mucosa
(metabolism)
- Humans
- Pancreatic Neoplasms
(diagnosis, metabolism)
- Stomach
(pathology)
|