Abstract | AIM: METHODS: RESULTS: Compared with group B, liver indices, levels of serum HA and ALT of groups C, D and E were reduced (liver indices: 0.038 +/- 0.008, 0.036 +/- 0.007, 0.036 +/- 0.005 vs 0.054 +/- 0.009, P < 0.05; HA: 502.33 +/- 110.57 ng/mL, 524.25 +/- 255.42 ng/mL, 499.25 +/- 198.10 ng/mL vs 828.50 +/- 237.83 ng/mL, P < 0.05; ALT: 149.44 +/- 16.51 U/L, 136.88 +/- 10.07 U/L, 127.38 +/- 11.03 U/L vs 203.25 +/- 31.62 U/L, P < 0.05), and SOD level was significantly higher, but MDA level was lower, in liver homogenates (SOD: 1.36 +/- 0.09 U/mg, 1.42 +/- 0.13 U/mg, 1.50 +/- 0.15 U/mg vs 1.08 +/- 0.19 U/mg, P < 0.05; MDA: 0.294 +/- 0.026 nmol/mg, 0.285 +/- 0.025 nmol/mg, 0.284 +/- 0.028 nmol/mg vs 0.335 +/- 0.056 nmol/mg, P < 0.05). Meanwhile, the stage of hepatic fibrosis was significantly weakened (P < 0.05). Compared with group A, the activity of GST liver homogenates and expression levels of Nrf2 and Nqo1 in group B were elevated (P < 0.05). The expression level of Nrf2 and Nqo1 in groups C, D, and E were increased as compared with group B, but the difference was not significant. CONCLUSION: Blueberry has preventive and protective effects on CCl(4)-induced hepatic fibrosis by reducing hepatocyte injury and lipid peroxidation. However, these effects may not be related to the activation of Nrf2 during long-term of CCl(4).
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Authors | Yu-Ping Wang, Ming-Liang Cheng, Bao-Fang Zhang, Mao Mu, Jun Wu |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 16
Issue 21
Pg. 2657-63
(Jun 07 2010)
ISSN: 2219-2840 [Electronic] United States |
PMID | 20518088
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- NF-E2-Related Factor 2
- Plant Preparations
- dan-shao-hua-xian
- Malondialdehyde
- Hyaluronic Acid
- Carbon Tetrachloride
- Superoxide Dismutase
- NAD(P)H Dehydrogenase (Quinone)
- NQO1 protein, rat
- Glutathione Transferase
- Alanine Transaminase
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Topics |
- Alanine Transaminase
(metabolism)
- Animals
- Blueberry Plants
(chemistry)
- Carbon Tetrachloride
(toxicity)
- Drugs, Chinese Herbal
(therapeutic use)
- Glutathione Transferase
(genetics, metabolism)
- Humans
- Hyaluronic Acid
(metabolism)
- Liver Cirrhosis
(chemically induced, drug therapy, pathology, prevention & control)
- Male
- Malondialdehyde
(metabolism)
- NAD(P)H Dehydrogenase (Quinone)
(genetics, metabolism)
- NF-E2-Related Factor 2
(genetics, metabolism)
- Phytotherapy
- Plant Preparations
(therapeutic use)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Superoxide Dismutase
(genetics, metabolism)
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