Abstract | BACKGROUND & OBJECTIVES: METHODS: Patients of OSMF (100) were randomly divided into two groups A and B. Group A patients received combination of hydrocortisone acetate (1.5 ml)/ hyaluronidase (1500 IU) at weekly interval submucosally in pterygomandibular raphe, half dose on each side for 22 wk. Group B patients received combination of triamcinolone acetonide (10 mg/ml)/ hyaluronidase (1500 IU) at 15 days interval for 22 wk. Treatment outcome was evaluated on the basis of improvement in symptom score, sign score and histopathological improvement. Student's 't' test was applied for comparing the results. RESULTS: No statistically significant difference in symptom score, sign score and histopathological improvement was seen between the two groups. INTERPRETATION & CONCLUSION: Treatment regimen of group B was more convenient to the patients because less number of visits required and cheap. No side effects were seen. A follow up study is required to see long term effects.
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Authors | Mangal Singh, H S Niranjan, Ravi Mehrotra, Devashish Sharma, S C Gupta |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 131
Pg. 665-9
(May 2010)
ISSN: 0971-5916 [Print] India |
PMID | 20516538
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- hydrocortisone acetate
- Hyaluronoglucosaminidase
- Triamcinolone Acetonide
- Hydrocortisone
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Topics |
- Adolescent
- Adult
- Aged
- Female
- Fibrosis
(drug therapy)
- Humans
- Hyaluronoglucosaminidase
(administration & dosage, therapeutic use)
- Hydrocortisone
(administration & dosage, analogs & derivatives, therapeutic use)
- Male
- Middle Aged
- Mouth Diseases
(drug therapy)
- Mucous Membrane
- Prospective Studies
- Single-Blind Method
- Triamcinolone Acetonide
(administration & dosage, therapeutic use)
- Young Adult
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