Abstract |
This study was designed to investigate whether the L/ N-type calcium channel blocker, cilnidipine, had a renoprotective effect compared with other calcium channel blockers. Twenty-five hypertensive patients with concomitant type 2 diabetes who had a urinary albumin- creatinine ratio (ACR) of 10 - 300 mg albumin/g creatinine and who had been treated with oral calcium channel blockers other than cilnidipine for more than 3 months were included. Patients' medication was changed to cilnidipine 10 mg/day or 20 mg/day without a washout period. Blood pressure and renal function were measured before and at 3 months after the new treatment. Heart rate was also determined as a marker for sympathetic nervous activity. After substitution of cilnidipine, blood pressure did not change significantly, but heart rate decreased significantly from 73.9 +/- 7.1 beats/min to 72.0 +/- 8.4 beats/min, and the log-transformed urinary ACR decreased to 82.9 +/- 49.4% of baseline values. The changes in urinary ACR and heart rate showed a significant positive correlation. Thus, there was a strong indication that cilnidipine may exert its renoprotective effect by inhibiting sympathetic nervous activity.
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Authors | M Tanaka |
Journal | The Journal of international medical research
(J Int Med Res)
2010 Mar-Apr
Vol. 38
Issue 2
Pg. 602-10
ISSN: 0300-0605 [Print] England |
PMID | 20515573
(Publication Type: Journal Article)
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Chemical References |
- Calcium Channel Blockers
- Calcium Channels, N-Type
- Dihydropyridines
- cilnidipine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Albuminuria
(drug therapy)
- Blood Pressure
(drug effects)
- Calcium Channel Blockers
(pharmacology)
- Calcium Channels, N-Type
(metabolism)
- Diabetes Complications
(drug therapy)
- Diabetes Mellitus, Type 2
(drug therapy)
- Dihydropyridines
(pharmacology)
- Female
- Heart Rate
(drug effects)
- Humans
- Hypertension
(complications, drug therapy)
- Kidney Function Tests
- Male
- Middle Aged
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