Distribution of 5-HT1B and 5-HT1D receptors in the inner ear.

Abstract

Migraine and anxiety disorders are frequently co-morbid with balance disorders. This study examined the relative distribution of subtypes of serotonin (5-HT) receptor in the inner ear of monkeys and rats. Most vestibular ganglion cells were immunoreactive for 5-HT(1B) and 5-HT(1D) receptors in macaques and rats. In the inner ear, 5-HT(1B) and 5-HT(1D) receptor immunopositivity was associated with endothelial cells of the vestibular ganglion, spiral ganglion, vestibulocochlear nerve, spiral ligament and stria vascularis. It was noteworthy that 5-HT(1B) and 5-HT(1D) receptors are expressed in parallel sites in peripheral vestibular and trigeminal systems, which may be a factor underlying the efficacy of triptans in treating migraine and migrainous vertigo. Because the vestibular ganglion and trigeminal ganglion are both within the subarachnoid space, an interaction between 5-HT(1B) and TRPV1 receptors on blood vessel and ganglion cells may also contribute to the vasospasm and the comorbid headache, dizziness, nausea and vomiting that accompany subarachnoid hemorrhage.

• Authors: Seong-Ki Ahn, Carey D Balaban
• Journal: Brain research (Brain Res) Vol. 1346 Pg. 92-101 (Jul 30 2010) ISSN: 1872-6240 [Electronic] Netherlands
• PMID: 20510890 (Publication Type: Journal Article)
• Copyright: Copyright 2010 Elsevier B.V. All rights reserved.

Chemical References

• Receptor, Serotonin, 5-HT1B
• Receptor, Serotonin, 5-HT1D
• TRPV Cation Channels
• TRPV1 receptor
• Tryptamines

Topics

• Animals
• Auditory Pathways (metabolism)
• Data Interpretation, Statistical
• Ear, Inner (metabolism)
• Immunohistochemistry
• Macaca mulatta
• Male
• Neural Pathways (metabolism)
• Rats
• Rats, Long-Evans
• Receptor, Serotonin, 5-HT1B (metabolism)
• Receptor, Serotonin, 5-HT1D (metabolism)
• TRPV Cation Channels (metabolism)
• Tryptamines (pharmacology)