Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells.

Abstract

The objective of this study was to determine the cytotoxicity, antiproliferative activity, and apoptosis induction activity of two modified glycosides - digoxin and proscillaridin A - conjugated to a generation 3 polyamidoamine dendrimer (G3 PAMAM-NH(2)) in human breast cancer cells. The results suggest that conjugation with the G3 PAMAM-NH(2) dendrimer enhances the cytotoxicity of modified digoxin and proscillaridin Aboth in MCF-7 and in MDA-MB-231 breast cancer cells. Additionally, the conjugate-induced apoptosis was significantly greater than apoptosis evoked by free modified digoxin and proscillaridin A.

• Authors: Katarzyna Winnicka, Krzysztof Bielawski, Anna Bielawska
• Journal: Pharmacological reports : PR (Pharmacol Rep) 2010 Mar-Apr Vol. 62 Issue 2 Pg. 414-23 ISSN: 2299-5684 [Electronic] Switzerland
• PMID: 20508299 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Dendrimers
• PAMAM Starburst
• Digoxin
• Proscillaridin

Topics

• Antineoplastic Agents (chemical synthesis)
• Apoptosis (drug effects)
• Breast Neoplasms (drug therapy, pathology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Dendrimers (chemical synthesis, pharmacology)
• Digoxin (analogs & derivatives, pharmacology)
• Female
• Humans
• Proscillaridin (analogs & derivatives, pharmacology)