Immunoglobulin A antibodies against desmoglein 1, envoplakin, periplakin and BP230 in a patient with atypical bullous pemphigoid.

Abstract

Bullous pemphigoid is an autoimmune subepidermal blistering disease associated with autoantibodies against BP180 and BP230. We report herein a rare case of bullous pemphigoid with newly formed annular erythematous lesions when bullous skin lesions were in remission. Various immunological studies revealed immunoglobulin (Ig)A antibodies against desmoglein 1, envoplakin, periplakin and BP230 in addition to IgG antibodies against BP180 and BP230. These clinical and immunological changes in a patient are a rare event, suggesting an epitope-spreading phenomenon.

• Authors: Fumi Yamaki, Nobuyasu Mayuzumi, Shigaku Ikeda, Takashi Hashimoto
• Journal: The Journal of dermatology (J Dermatol) Vol. 37 Issue 3 Pg. 255-8 (Mar 2010) ISSN: 1346-8138 [Electronic] England
• PMID: 20507390 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Desmoglein 1
• Immunoglobulin A
• Membrane Proteins
• PPL protein, human
• Plakins
• Protein Precursors
• envoplakin
• Dapsone
• Prednisolone

Topics

• Aged, 80 and over
• Autoantibodies (blood, immunology)
• Basement Membrane (immunology)
• Dapsone (therapeutic use)
• Desmoglein 1 (immunology)
• Female
• Humans
• Immunoglobulin A (blood, immunology)
• Membrane Proteins (immunology)
• Pemphigoid, Bullous (drug therapy, immunology)
• Plakins (immunology)
• Prednisolone (therapeutic use)
• Protein Precursors (immunology)