A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice.

Abstract

BACKGROUND AND AIM:

Several dentifrices have shown to be effective in reducing dentine hypersensitivity (DH), but more effective products are needed. The aim of the study was to evaluate the desensitizing efficacy of a new dentifrice based on zinc-carbonate hydroxyapatite (CHA) nanocrystals.

METHODS AND MATERIALS:

Using a double-blind, randomized design, the new dentifrice was compared with potassium nitrate/fluoride dentifrice (active control). The participant's DH was evaluated at baseline and after 4 and 8 weeks using airblast (primary outcome), tactile, cold water and subjective tests (secondary outcomes).

RESULTS:

The final sample consisted of 70 subjects with baseline DH; 36 received the new dentifrice and 34 the control one. Both dentifrices were largely effective; the percentage of score reduction from baseline to 8 weeks was greater than 28% for all tests (and greater than 55% for the cold water test) in both groups. As compared with controls, experimental subjects had a significantly greater improvement in the airblast test score (mean percentage of reduction of 46.0%versus 29.4% in controls) and the subjective test score (47.5%versus 28.1%, respectively), with both differences already being significant after 4 weeks. In contrast, there was no significant difference between groups for either the tactile or cold water tests at any time point and with any outcome.

CONCLUSIONS:

This study documented that the new dentifrice containing zinc-CHA nanocrystals significantly reduced dentinal hypersensitivity after 4 and 8 weeks, supporting its utility in clinical practice.

• Authors: Giovanna Orsini, Maurizio Procaccini, Lamberto Manzoli, Francesca Giuliodori, Alessandro Lorenzini, Angelo Putignano
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 37 Issue 6 Pg. 510-7 (Jun 2010) ISSN: 1600-051X [Electronic] United States
• PMID: 20507374 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Apatites
• Biocompatible Materials
• Carbonates
• Dentifrices
• Dentin Desensitizing Agents
• Drug Combinations
• Nitrates
• Phosphates
• Potassium Compounds
• Sensodyne
• Zinc Compounds
• Water
• carboapatite
• Sodium Fluoride
• Durapatite
• zinc carbonate
• Fluorides
• potassium nitrate

Topics

• Adult
• Air
• Apatites (therapeutic use)
• Biocompatible Materials (therapeutic use)
• Carbonates (therapeutic use)
• Cold Temperature
• Dentifrices (therapeutic use)
• Dentin Desensitizing Agents (therapeutic use)
• Dentin Sensitivity (classification, therapy)
• Double-Blind Method
• Drug Combinations
• Durapatite (therapeutic use)
• Female
• Fluorides (therapeutic use)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Nanoparticles (therapeutic use)
• Nitrates (therapeutic use)
• Phosphates (therapeutic use)
• Physical Stimulation
• Potassium Compounds (therapeutic use)
• Sodium Fluoride (therapeutic use)
• Touch
• Treatment Outcome
• Water
• Zinc Compounds (therapeutic use)