The use of local
antibiotics from a
biodegradable implant for chronic
osteomyelitis is an attractive alternative. The implant delivers high
antibiotic concentration at tissue levels, obliterates dead space,
aids bone repair and does not need to be removed. The purpose of this paper is to develop and evaluate a
calcium sulphate and
polycaprolactone based composite biodegradable implantable delivery system of
cefoperazone sodium. Implants were prepared by modified fabrication technique to avoid
solvent use. Interaction studies were carried out to check any incompatibility between ingredients. Prepared implants were evaluated for various in vitro parameters like dimensions, hardness, tensile strength, drug release profile and
sterility. Morphological changes in pellet before and after drug release were evaluated by scanning electron microscopy. The pellet were also tested for microbiological efficacy and compared with plain
drug solution in different concentrations. Developed pellets are regular in shape and size with good tensile strength. The release profile displayed
drug levels above MIC continuously up to 2 months. Wide zone of inhibition by pellet against Staph. aureus as compared to
drug solution proves its efficacy in treatment of
osteomyelitis.