The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer.

Abstract

BACKGROUND:

For locally advanced squamous cell carcinoma of the head and neck (HNSCC), the recurrence rate after surgery and postoperative radiotherapy is between 20 and 40%, and the 5-year overall survival rate is approximately 50%. Presently, no markers exist to accurately predict treatment outcome. Expression of proteins in the human epidermal growth factor receptor (EGFR) pathway has been reported as a prognostic marker in several types of cancer.

METHODS:

The aim of this study was to investigate the prognostic value of proteins in the EGFR pathway in HNSCC. For this purpose, we collected surgically resected tissue of 140 locally advanced head and neck cancer patients, all treated with surgery and postoperative radiotherapy.

RESULTS:

In a multivariate analysis, expression of the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) was significantly related to worse locoregional control (LRC; HR: 2.2, 95% CI: 1.1-4.6; P=0.03), independent of lymph node metastases (HR: 5.6, 95% CI: 1.2-27.4; P=0.03) and extranodal spread (HR: 2.7; 95% CI: 1.2-6.5; P=0.02). In vitro clonogenic radiosensitivity assays confirmed that overexpression of PTEN resulted in increased radioresistance.

CONCLUSION:

Our study is the first report showing that expression of PTEN mediates radiosensitivity in vitro and that increased expression in advanced HNSCC predicts worse LRC.

• Authors: W J Pattje, E Schuuring, M F Mastik, L Slagter-Menkema, M L Schrijvers, S Alessi, B F A M van der Laan, J L N Roodenburg, J A Langendijk, J E van der Wal
• Journal: British journal of cancer (Br J Cancer) Vol. 102 Issue 12 Pg. 1778-85 (Jun 08 2010) ISSN: 1532-1827 [Electronic] England
• PMID: 20502457 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Biomarkers, Tumor
• EGFR protein, human
• ERBB2 protein, human
• ErbB Receptors
• Receptor, ErbB-2
• PTEN Phosphohydrolase

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (genetics, radiotherapy)
• Chromosomes, Human, Pair 10
• ErbB Receptors (metabolism)
• Female
• Gene Deletion
• Head and Neck Neoplasms (genetics, radiotherapy)
• Humans
• Lymphatic Metastasis
• Male
• Middle Aged
• PTEN Phosphohydrolase (genetics)
• Prognosis
• Radiation Tolerance (genetics)
• Receptor, ErbB-2 (metabolism)
• Signal Transduction