Abstract | OBJECTIVE: DATA SOURCES: We searched the PubMed database up to December 2009 for English-language studies using the key words " aspirin AND ( heparin OR low molecular weight heparin), (antiphospholipid OR anticardiolipin OR aPL) AND pregnancy." METHODS OF STUDY SELECTION: TABULATION, INTEGRATION, AND RESULTS: The pooled effect of unfractionated heparin and low molecular weight heparin was evaluable in three and two randomized controlled studies, respectively, with regard to live births, which was the major outcome. Overall, treatment effects were in favor of heparin against first-trimester losses (odd ratio [OR] 0.39, 95% confidence interval [CI] 0.24-0.65, number needed to treat 6). More specifically, unfractionated heparin displayed a significant effect (OR 0.26, 95% CI 0.14-0.48, number needed to treat 4), while the pooled effect of low molecular weight heparin was insignificant (OR 0.70, 95% CI 0.34-1.45). Combination therapy of either unfractionated heparin or low molecular weight heparin with aspirin failed to display any significant effect in the prevention of late-pregnancy losses. No significant differences were observed between treatment and control groups for any other outcomes. CONCLUSION:
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Authors | Panayiotis D Ziakas, Matthaios Pavlou, Michael Voulgarelis |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 115
Issue 6
Pg. 1256-1262
(Jun 2010)
ISSN: 1873-233X [Electronic] United States |
PMID | 20502298
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Fibrinolytic Agents
- Heparin
- Aspirin
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Topics |
- Abortion, Habitual
(etiology, prevention & control)
- Antiphospholipid Syndrome
(complications, drug therapy)
- Aspirin
(therapeutic use)
- Drug Therapy, Combination
- Female
- Fibrinolytic Agents
(therapeutic use)
- Heparin
(therapeutic use)
- Humans
- Pregnancy
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