HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Mesodermal Tbx1 is required for patterning the proximal mandible in mice.

Abstract
Defects in the lower jaw, or mandible, occur commonly either as isolated malformations or in association with genetic syndromes. Understanding its formation and genetic pathways required for shaping its structure in mammalian model organisms will shed light into the pathogenesis of malformations in humans. The lower jaw is derived from the mandibular process of the first pharyngeal arch (MdPA1) during embryogenesis. Integral to the development of the mandible is the signaling interplay between Fgf8 and Bmp4 in the rostral ectoderm and their downstream effector genes in the underlying neural crest derived mesenchyme. The non-neural crest MdPA1 core mesoderm is needed to form muscles of mastication, but its role in patterning the mandible is unknown. Here, we show that mesoderm specific deletion of Tbx1, a T-box transcription factor and gene for velo-cardio-facial/DiGeorge syndrome, results in defects in formation of the proximal mandible by shifting expression of Fgf8, Bmp4 and their downstream effector genes in mouse embryos at E10.5. This occurs without significant changes in cell proliferation or apoptosis at the same stage. Our results elucidate a new function for the non-neural crest core mesoderm and specifically, mesodermal Tbx1, in shaping the lower jaw.
AuthorsVimla S Aggarwal, Courtney Carpenter, Laina Freyer, Jun Liao, Marilena Petti, Bernice E Morrow
JournalDevelopmental biology (Dev Biol) Vol. 344 Issue 2 Pg. 669-81 (Aug 15 2010) ISSN: 1095-564X [Electronic] United States
PMID20501333 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright 2010 Elsevier Inc. All rights reserved.
Chemical References
  • Bone Morphogenetic Protein 4
  • FGF8 protein, human
  • Fetal Proteins
  • T-Box Domain Proteins
  • Fibroblast Growth Factor 8
  • Brachyury protein
Topics
  • Animals
  • Bone Morphogenetic Protein 4
  • Branchial Region (metabolism)
  • Crosses, Genetic
  • DiGeorge Syndrome (genetics, metabolism)
  • Ectoderm (metabolism)
  • Embryo, Mammalian
  • Embryonic Development (genetics)
  • Fetal Proteins
  • Fibroblast Growth Factor 8
  • Heart
  • Humans
  • Male
  • Mandible (metabolism)
  • Mesoderm (metabolism)
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Mutant Strains
  • Mice, Transgenic
  • Neural Crest
  • T-Box Domain Proteins

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: