IL-8 in cerebrospinal fluid from children with acute encephalopathy is higher than in that from children with febrile seizure.

Abstract

We identify possible differences in the cytokine/chemokine profiles in cerebrospinal fluid (CSF) from children with encephalopathy and febrile seizure. Interleukin (IL)-1beta, 2, 4, 5, 6, 7, 8, 10, 12, 13, 17, interferon-gamma, tumour necrosis factor-alpha, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1beta were measured simultaneously in CSF supernatants from children with encephalopathy (n = 8), febrile seizure (n = 16) and fever without neurological complications (n = 8). IL-8 in CSF from children with encephalopathy was significantly elevated compared to that in CSF from children with febrile seizure and fever without neurological complications. IL-8 in CSF was also higher than serum IL-8, suggesting that increased IL-8 was generated from glia cells or astrocytes, not by leakage from serum. Increased IL-8 in CSF in encephalopathy may protect against severe brain damage.

• Authors: T Asano, K Ichiki, S Koizumi, K Kaizu, T Hatori, O Fujino, K Mashiko, Y Sakamoto, T Miyasho, Y Fukunaga
• Journal: Scandinavian journal of immunology (Scand J Immunol) Vol. 71 Issue 6 Pg. 447-51 (Jun 2010) ISSN: 1365-3083 [Electronic] England
• PMID: 20500697 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CCL4 protein, human
• Chemokine CCL2
• Chemokine CCL4
• Interleukins
• Tumor Necrosis Factor-alpha
• Granulocyte Colony-Stimulating Factor
• Interferon-gamma
• Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• Chemokine CCL2 (cerebrospinal fluid, immunology)
• Chemokine CCL4 (cerebrospinal fluid, immunology)
• Child, Preschool
• Encephalitis (cerebrospinal fluid, immunology)
• Female
• Granulocyte Colony-Stimulating Factor (cerebrospinal fluid, immunology)
• Granulocyte-Macrophage Colony-Stimulating Factor (cerebrospinal fluid, immunology)
• Humans
• Immunoassay
• Infant
• Interferon-gamma (cerebrospinal fluid, immunology)
• Interleukins (cerebrospinal fluid, immunology)
• Male
• Seizures, Febrile (cerebrospinal fluid, immunology)
• Statistics, Nonparametric
• Tumor Necrosis Factor-alpha (cerebrospinal fluid, immunology)