Abstract | BACKGROUND: METHODS: A total of 174 male ICR mice were randomized to receive an IT injection of equimolar dose of glycine, betaine, beta-alanine, or taurine in combination with STR or BIC. Agitation in response to innocuous stimulation with a von Frey filament after IT injection was assessed. The pain index in hot-plate test were observed after IT injection. The effect of IT muscimol in combination with STR or BIC were also observed. RESULTS: CONCLUSIONS: This study suggests that IT glycine and related amino acids can reduce the allodynic and hyperalgesic action of STR or BIC in mice.
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Authors | Eui Sung Lim, Il Ok Lee |
Journal | Korean journal of anesthesiology
(Korean J Anesthesiol)
Vol. 58
Issue 1
Pg. 76-86
(Jan 2010)
ISSN: 2005-7563 [Electronic] Korea (South) |
PMID | 20498816
(Publication Type: Journal Article)
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