Abstract | BACKGROUND: Presently melanoma still lacks adequate treatment options for metastatic disease. While melanoma is exceptionally challenging to standard regimens, it is suited for treatment with immunotherapy based on its immunogenicity. Since treatment-related skin depigmentation is considered a favourable prognostic sign during melanoma intervention, we here aimed at the reverse approach of directly inducing vitiligo as a shortcut to effective anti- melanoma immunity. METHODOLOGY AND PRINCIPAL FINDINGS: CONCLUSIONS: MIC therapy is effective in eradicating melanoma, by vigilantly incorporating NK-, B- and T cells in its therapeutic effect. Based on these results, the MIC regimen presents a high-yield, low-cost and simple therapy, readily applicable in the clinic.
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Authors | Jasper G van den Boorn, Debby Konijnenberg, Esther P M Tjin, Daisy I Picavet, Nico J Meeuwenoord, Dmitri V Filippov, J P Wietze van der Veen, Jan D Bos, Cornelis J M Melief, Rosalie M Luiten |
Journal | PloS one
(PLoS One)
Vol. 5
Issue 5
Pg. e10626
(May 13 2010)
ISSN: 1932-6203 [Electronic] United States |
PMID | 20498710
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adjuvants, Immunologic
- Aminoquinolines
- Dinucleoside Phosphates
- Hydroquinones
- Immunoglobulin G
- cytidylyl-3'-5'-guanosine
- monobenzone
- Imiquimod
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Topics |
- Adjuvants, Immunologic
(therapeutic use)
- Aminoquinolines
(administration & dosage, pharmacology, therapeutic use)
- Animals
- CD8-Positive T-Lymphocytes
(drug effects, immunology, pathology)
- Cell Proliferation
(drug effects)
- Dinucleoside Phosphates
(administration & dosage, pharmacology, therapeutic use)
- Hydroquinones
(administration & dosage, pharmacology, therapeutic use)
- Imiquimod
- Immunoglobulin G
(immunology)
- Immunotherapy
- Injections, Subcutaneous
- Killer Cells, Natural
(drug effects, immunology, pathology)
- Leukocyte Count
- Lymphocyte Activation
(drug effects)
- Lymphocyte Depletion
- Melanoma
(drug therapy, immunology)
- Mice
- Mice, Inbred C57BL
- Pigmentation
(drug effects)
- Skin Neoplasms
(drug therapy, immunology)
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