Effects of sodium o-iodobenzoate on acid-base parameters and survival in dogs with hemorrhagic shock.

Abstract

Sodium o-iodobenzoate (OISB) produces an increase in P50 (PO2 at 50% of oxyhemoglobin saturation) and survival when infused at the time of initiation of prolonged hemorrhagic shock in dogs. Acid-base parameters improved during treatment, and plasma lactic acid concentrations showed smaller rises than in nontreated control animals. Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) rose in prolonged hemorrhagic shock in the control group and conversely decreased in OISB-treated dogs. OISB did not require red cell integrity, since its effects were still more marked in hemolyzed blood. The therapeutic benefit of OISB, appears to be related to a direct effect of the agent on the hemoglobin molecule.

• Authors: C F Bercovich, C J Pirola, S Finkielman, V E Nahmod
• Journal: Circulatory shock (Circ Shock) Vol. 33 Issue 2 Pg. 63-7 (Feb 1991) ISSN: 0092-6213 [Print] United States
• PMID: 2049815 (Publication Type: Journal Article)

Chemical References

• Bicarbonates
• Diphosphoglyceric Acids
• Iodobenzoates
• Lactates
• 2,3-Diphosphoglycerate
• Lactic Acid
• 2-iodobenzoic acid
• Oxygen

Topics

• 2,3-Diphosphoglycerate
• Acidosis (drug therapy, etiology)
• Animals
• Bicarbonates (blood)
• Diphosphoglyceric Acids (blood)
• Dogs
• Erythrocytes (metabolism)
• Female
• Iodobenzoates (therapeutic use)
• Lactates (blood)
• Lactic Acid
• Male
• Oxygen (blood)
• Shock, Hemorrhagic (blood, complications, drug therapy)