Abstract | OBJECTIVE: METHODS: Polymerase chain reaction-specific sequence primers (PCR-SSP) method was used to type HLA-DRB1 subregions in 94 Han children with JIA and 226 Han healthy controls. RESULTS: The frequency of HLA-DRB1*08 allele in the JIA group was significantly higher than that in the control group (P=0.0014, OR=2.26), in contrast, the frequency of HLA-DRB1*12 allele was significantly lower than that in the control group (P=0.032, OR=0.55). It was found that in children with So-JIA subset (P=0.023, OR=2.25) and polyarthritis JIA subset (P=0.034, OR=2.81), the allele HLA-DRB1*08 was expressed most commonly. The allele HLA-DRB1*15 was expressed in a lower frequency in children with So-JIA subset (P=0.049, OR=0.413) and oligoarthritis subset (P=0.045, OR=0.16) compared with that in the control group. CONCLUSIONS:
HLA-DRB1*08 may be the susceptible allele of JIA, while HLA-DRB1*12 may be the protective allele of JIA in Han children from Guangdong Province. HLA-DRB1*08 is the susceptible allele of So-JIA and polyarthrits. HLA-DRB1*15 is the protective allele for systemic JIA and oligoarthritis.
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Authors | Juan Wu, Hua-Song Zeng |
Journal | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
(Zhongguo Dang Dai Er Ke Za Zhi)
Vol. 12
Issue 5
Pg. 333-7
(May 2010)
ISSN: 1008-8830 [Print] China |
PMID | 20497637
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA-DR Antigens
- HLA-DRB1 Chains
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Topics |
- Adolescent
- Adult
- Aged
- Alleles
- Arthritis, Juvenile
(genetics)
- Female
- Genetic Predisposition to Disease
- HLA-DR Antigens
(genetics)
- HLA-DRB1 Chains
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
- Young Adult
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