Abstract | INTRODUCTION: METHODS: RESULTS: EE was found to suppress clinical signs and symptoms in rat AA. The selective ERbeta agonist ERB-79 had no effect on arthritis symptoms in this model. In the TT-specific DTH model, EE and the selective ERalpha agonist ERA-63 suppressed the TT-specific swelling response in WT and ERbetaKO mice but not in ERalphaKO mice. As seen in the AA model, the selective ERbeta agonist ERB-79 did not suppress inflammation. Treatment with EE or ERA-63 suppressed clinical signs in collagen induced arthritis (CIA) in WT mice. This was associated with reduced inflammatory infiltrates and decreased levels of proinflammatory cytokines in CIA joints. CONCLUSIONS:
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Authors | John Dulos, Peter Vijn, Cindy van Doorn, Claudia L Hofstra, Desiree Veening-Griffioen, Jan de Graaf, Fred A Dijcks, Annemieke M H Boots |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 12
Issue 3
Pg. R101
( 2010)
ISSN: 1478-6362 [Electronic] England |
PMID | 20497523
(Publication Type: Journal Article)
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Chemical References |
- (7-alpha,17-alpha)-7-methyl-3-methylene-19-norpregn-5(10)-en-20-yn-17-ol
- Cytokines
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Tetanus Toxoid
- Ethinyl Estradiol
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Topics |
- Animals
- Arthritis, Experimental
(drug therapy, metabolism)
- Cytokines
(metabolism)
- Disease Models, Animal
- Estrogen Receptor alpha
(agonists, genetics, metabolism)
- Estrogen Receptor beta
(agonists, genetics, metabolism)
- Ethinyl Estradiol
(analogs & derivatives, therapeutic use)
- Female
- Hypersensitivity, Delayed
(chemically induced, drug therapy)
- Inflammation
(metabolism)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Knockout
- Rats
- Synovial Membrane
(metabolism)
- Tetanus Toxoid
(adverse effects)
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