Abstract | BACKGROUND: METHODS: RESULTS: CONCLUSIONS: These data, generated in a rigorous, high-viral-load SIV-infected macaque model, showed that HAART provided benefits with respect to CNS viral replication and inflammation but that no change in the level of viral DNA and continued CNS inflammation occurred in some macaques.
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Authors | M Christine Zink, Angela K Brice, Kathleen M Kelly, Suzanne E Queen, Lucio Gama, Ming Li, Robert J Adams, Christopher Bartizal, John Varrone, S Alireza Rabi, David R Graham, Patrick M Tarwater, Joseph L Mankowski, Janice E Clements |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 202
Issue 1
Pg. 161-70
(Jul 01 2010)
ISSN: 1537-6613 [Electronic] United States |
PMID | 20497048
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Anti-HIV Agents
- Biomarkers
- Cytokines
- DNA, Viral
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Topics |
- Adaptive Immunity
- Animals
- Anti-HIV Agents
(therapeutic use)
- Antiretroviral Therapy, Highly Active
- Biomarkers
- Central Nervous System Diseases
(drug therapy, virology)
- Cytokines
(cerebrospinal fluid, genetics, metabolism)
- DNA, Viral
- Immunity, Innate
- Inflammation
(drug therapy, virology)
- Macaca mulatta
- Simian Acquired Immunodeficiency Syndrome
(complications, drug therapy)
- Simian Immunodeficiency Virus
- Viral Load
- Virus Replication
(drug effects)
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