[How to choose correct proton pump inhibitors to patients with GERD?].

Abstract

Proton pump inhibitors (PPI) are most effective for the gastroesophageal reflux disease (GERD) treatment. The effectiveness of PPI in the long-term treatment of GERD is similar. However, the PPI are different according to fast onset and duration of antisecretory action, pH-selectivity, metabolism, interactions with other medicines and dosage forms. In some clinical situations, these differences can be significant. In this article was described features of the pharmacokinetics of PPI. It was shown that the early stages of treatment of certain advantages in speed of onset of effect is lansoprazole, which potentially increases the patient's adherence to treatment. Metabolism in the cytochrome P450 system provides the lowest profile of pantoprazole drug interactions, making it the most secure in the presence of GERD in a patient comorbidities and need for drugs used to treat it.

• Authors: D S Bordin
• Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology (Eksp Klin Gastroenterol) Issue 2 Pg. 53-8 ( 2010) ISSN: 1682-8658 [Print] Russia (Federation)
• PMID: 20496811 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Proton Pump Inhibitors
• Lansoprazole
• Cytochrome P-450 Enzyme System

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles (pharmacokinetics, therapeutic use)
• Cytochrome P-450 Enzyme System (metabolism)
• Drug Interactions
• Gastroesophageal Reflux (drug therapy, enzymology)
• Humans
• Lansoprazole
• Proton Pump Inhibitors (pharmacokinetics, therapeutic use)
• Time Factors