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Synthesis of cytotoxic and antioxidant Schiff's base analogs of aloin.

Abstract
Aloin (10-glucopyranosyl-1,8-dihydroxy-3-hydroxymethyl-9(10H)-anthracenone), a bioactive compound in Aloe vera, although known to have an anticancer effect, has not been used in current drug research. Optimization of the lead structure could enhance the utility of this compound. Hence, aloin was modified using natural amino acids to produce Schiff's base, a potential pharmacophore, and its corresponding aglycones. The synthetic derivatives exhibited significant enhancement in their efficacy toward antioxidant (DPPH radical scavenging) and cytotoxic activities than those of the parent compound, aloin showing promise for application in cancer treatment.
AuthorsS Kumar, D Priya Matharasi, Sreeraj Gopi, S Sivakumar, S Narasimhan
JournalJournal of Asian natural products research (J Asian Nat Prod Res) Vol. 12 Issue 5 Pg. 360-70 (May 2010) ISSN: 1477-2213 [Electronic] England
PMID20496193 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Biphenyl Compounds
  • Picrates
  • Schiff Bases
  • 1,1-diphenyl-2-picrylhydrazyl
  • Emodin
  • alloin
Topics
  • Aloe (chemistry)
  • Animals
  • Antineoplastic Agents, Phytogenic (chemical synthesis, chemistry, pharmacology)
  • Antioxidants (chemical synthesis, chemistry, pharmacology)
  • Artemia (drug effects)
  • Biphenyl Compounds (pharmacology)
  • Combinatorial Chemistry Techniques
  • Emodin (analogs & derivatives, chemical synthesis, chemistry, pharmacology)
  • Molecular Structure
  • Picrates (pharmacology)
  • Plants, Medicinal (chemistry)
  • Schiff Bases (pharmacology)

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