Abstract | BACKGROUND: OBJECTIVES: METHODS: In a prospective randomized within-patient controlled study, 13 patients with a prurigo form of AD were randomized to receive EL on one side and topical CP on the other side. Laser treatment was performed twice a week for 10 weeks. Clinical responses were evaluated using Physician Assessment of Individual Signs, Physician Global Assessment, Patient Global Assessment and photographic documentation. Histopathological changes were evaluated and duration of remission was monitored during a 6-month follow-up period. RESULTS: Both treatments resulted in a significant improvement of all outcome measures after 10 weeks of treatment. During follow up, the EL showed more improvement compared with CP. Histopathology demonstrated marked decrease of epidermal thickness and inflammatory infiltrate at the EL-treated sites. No significant side-effects occurred. CONCLUSIONS: This study suggests that the EL can safely and effectively be used in the treatment of the prurigo form of AD. For the long term, the EL might be a good alternative to topical corticosteroids and an option in case of therapy-resistant patients.
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Authors | E E A Brenninkmeijer, P I Spuls, R Lindeboom, A C van der Wal, J D Bos, A Wolkerstorfer |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 163
Issue 4
Pg. 823-31
(Oct 2010)
ISSN: 1365-2133 [Electronic] England |
PMID | 20491772
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists. |
Chemical References |
- Dermatologic Agents
- Glucocorticoids
- Clobetasol
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Topics |
- Adult
- Aged
- Biopsy
- Clobetasol
(adverse effects, therapeutic use)
- Dermatitis, Atopic
(drug therapy, pathology, surgery)
- Dermatologic Agents
(adverse effects, therapeutic use)
- Epidemiologic Methods
- Female
- Glucocorticoids
(adverse effects, therapeutic use)
- Humans
- Lasers, Excimer
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Prurigo
(drug therapy, pathology, surgery)
- Skin
(pathology)
- Treatment Outcome
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