Abstract | OBJECTIVES: The rhizome of Atractylodes ovata De Candolle is popularly used in traditional Chinese medicine to treat gastrointestinal diseases. However, the major gastroprotective compounds of A. ovata have not been identified. This study reports on the principal gastro- protective component of A. ovata. METHODS: KEY FINDINGS: CONCLUSIONS:
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Authors | Kun-Teng Wang, Lih-Geeng Chen, Chih-Hsiung Wu, Chun-Chao Chang, Ching-Chiung Wang |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 62
Issue 3
Pg. 381-8
(Mar 2010)
ISSN: 2042-7158 [Electronic] England |
PMID | 20487223
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Ulcer Agents
- Drugs, Chinese Herbal
- Lactones
- Protein Isoforms
- Sesquiterpenes
- Tissue Inhibitor of Metalloproteinases
- atractylenolide III
- Ethanol
- Matrix Metalloproteinases, Secreted
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Topics |
- Animals
- Anti-Ulcer Agents
(isolation & purification, pharmacology, therapeutic use)
- Atractylodes
(chemistry)
- Cell Membrane
(drug effects)
- Cell Survival
(drug effects)
- Cells, Cultured
- Dose-Response Relationship, Drug
- Drug Discovery
- Drugs, Chinese Herbal
(chemistry)
- Ethanol
(administration & dosage, toxicity)
- Gastric Mucosa
(cytology, drug effects, metabolism)
- Lactones
(isolation & purification, pharmacology, therapeutic use)
- Male
- Matrix Metalloproteinases, Secreted
(metabolism)
- Protein Isoforms
(metabolism)
- Rats
- Rats, Wistar
- Rhizome
(chemistry)
- Sesquiterpenes
(isolation & purification, pharmacology, therapeutic use)
- Severity of Illness Index
- Stomach Ulcer
(drug therapy, metabolism, pathology)
- Tissue Inhibitor of Metalloproteinases
(metabolism)
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