Abstract | OBJECTIVES: Increased production and accumulation of melanin leads to many hyperpigmentation disorders such as melasma, freckles and geriatric pigment spots. Thus, there is a need for the development of depigmenting agents. Based on our previous reports, selenium derivatives as anti-melanogenic lead compounds could be very important. The aim of this study was to investigate the depigmenting effect of novel selenium-containing compounds. METHODS: KEY FINDINGS: We found that CS1 inhibited melanin production in B16F10 cells by suppressing tyrosinase activity and its protein expression. In addition, Western blotting analysis revealed that CS1 suppressed the expression of tyrosinase-related protein (TRP)-1 and TRP-2. Therefore, the depigmenting effect of CS1 might have been due to inhibition of tyrosinase activity and expression of melanogenic enzymes. Furthermore, CS1 had inhibitory effects on melanin biosynthesis of primary cultured skin of brownish guinea pig. CONCLUSIONS: The results suggested that CS1 could be a useful candidate for the treatment of skin hyperpigmentation.
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Authors | Eunjoo H Lee, Yu-Ji Lim, Sang Keun Ha, Tong Ho Kang, Mamoru Koketsu, Chulhun Kang, Sun Yeou Kim, Ji-Ho Park |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 62
Issue 3
Pg. 352-9
(Mar 2010)
ISSN: 2042-7158 [Electronic] England |
PMID | 20487219
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 5-chloroacetyl-2-piperidino-1,3-selenazole
- Enzyme Inhibitors
- Fungal Proteins
- Melanins
- Membrane Glycoproteins
- Organoselenium Compounds
- Selenium Compounds
- alpha-MSH
- Oxidoreductases
- Tyrp1 protein, mouse
- Monophenol Monooxygenase
- Intramolecular Oxidoreductases
- dopachrome isomerase
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Topics |
- Animals
- Cell Survival
(drug effects)
- Down-Regulation
(drug effects)
- Drug Evaluation, Preclinical
- Enzyme Inhibitors
(pharmacology)
- Fungal Proteins
(antagonists & inhibitors, metabolism)
- Guinea Pigs
- Hyperpigmentation
(drug therapy)
- Intramolecular Oxidoreductases
(metabolism)
- Melanins
(biosynthesis, metabolism)
- Melanoma
(enzymology, metabolism)
- Membrane Glycoproteins
(metabolism)
- Mice
- Monophenol Monooxygenase
(antagonists & inhibitors, metabolism)
- Organ Culture Techniques
- Organoselenium Compounds
(pharmacology)
- Osmolar Concentration
- Oxidoreductases
(metabolism)
- Selenium Compounds
(pharmacology)
- Skin
(cytology, drug effects, metabolism)
- Tumor Cells, Cultured
- alpha-MSH
(pharmacology)
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