Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain.

Abstract

OBJECTIVES:

In the present study we investigated the antinociceptive, anti-inflammatory and antipyretic effects of 7-hydroxycoumarin (7-HC) in animal models.

METHODS:

The effects of oral 7-HC were tested against acetic acid-induced writhing, formalin test, tail flick test, complete Freund's adjuvant (CFA)-induced hypernociception, carrageenan-induced paw oedema, lipopolysaccharide-induced fever and the rota rod test.

KEY FINDINGS:

7-HC (3-60 mg/kg) produced a dose-related antinociception against acetic acid-induced writhing in mice and in the formalin test. In contrast, treatment with 7-HC did not prevent thermal nociception in the tail flick test. A single treatment with 7-HC, 60 mg/kg, produced a long-lasting antinociceptive effect against CFA-induced hypernociception, a chronic inflammatory pain stimulus. Notably, at 60 mg/kg per day over 4 days the administration of 7-HC produced a continuous antinociceptive effect against CFA-induced hypernociception. 7-HC (30-120 mg/kg) produced anti-inflammatory and antipyretic effects against carrageenan-induced inflammation and lipopolysaccharide-induced fever, respectively. Moreover, 7-HC was found to be safe with respect to ulcer induction. In the rota rod test, 7-HC-treated mice did not show any motor performance alterations.

CONCLUSIONS:

The prolonged antinociceptive and anti-inflammatory effects of 7-HC, in association with its low ulcerogenic activity, indicate that this molecule might be a good candidate for development of new drugs for the control of chronic inflammatory pain and fever.

• Authors: Taís A de Almeida Barros, Luis A R de Freitas, José M B Filho, Xirley P Nunes, Ana M Giulietti, Glória E de Souza, Ricardo R dos Santos, Milena B P Soares, Cristiane F Villarreal
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 62 Issue 2 Pg. 205-13 (Feb 2010) ISSN: 2042-7158 [Electronic] England
• PMID: 20487200 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Umbelliferones
• 7-hydroxycoumarin

Topics

• Acute Disease
• Administration, Oral
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects, pharmacology, therapeutic use)
• Chronic Disease
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Edema (drug therapy)
• Fever (drug therapy)
• Inflammation (drug therapy)
• Male
• Mice
• Motor Activity (drug effects)
• Pain (drug therapy)
• Pain Measurement
• Rats
• Rats, Wistar
• Umbelliferones (administration & dosage, adverse effects, pharmacology, therapeutic use)